Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.700 AlteredExpression LHGDN Coamplified and overexpressed genes at ERBB2 locus in gastric cancer. 14991576

2004

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.700 AlteredExpression LHGDN Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer. 18483367

2008

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.700 AlteredExpression LHGDN Role of receptor tyrosine kinases in gastric cancer: new targets for a selective therapy. 16733844

2006

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.700 AlteredExpression LHGDN Membranous levels of c-erbB-2 oncoprotein in gastric cancer: their relationship with clinicopathological parameters and their prognostic significance. 15646832

2005

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.620 AlteredExpression LHGDN FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. 18381441

2008

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.620 AlteredExpression LHGDN Mutations of PIK3CA in gastric adenocarcinoma. 15784156

2005

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.600 AlteredExpression LHGDN The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers. 18427545

2008

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.600 AlteredExpression LHGDN Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells. 18377425

2008

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.580 AlteredExpression LHGDN Gastrin and c-met protein expression were significantly higher in gastric tumor tissue than in IM (P<0.0001). 14719064

2004

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.500 AlteredExpression LHGDN Maspin and p53 protein expression in gastric adenocarcinoma and its clinical applications. 18091326

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.500 AlteredExpression LHGDN The evaluation of gastric cancer sensitivity to 5-FU/CDDP in terms of induction of apoptosis: time- and p53 expression-dependency of anti-cancer drugs. 16077963

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.500 AlteredExpression LHGDN [Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior]. 12452062

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.500 AlteredExpression LHGDN Helicobacter pylori infection generated gastric cancer through p53-Rb tumor-suppressor system mutation and telomerase reactivation. 12508351

2003

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.500 AlteredExpression LHGDN The data on p53 abnormalities, when considered separately, could be of relative value for predicting the behavior of gastric tumors. 17436385

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.500 AlteredExpression LHGDN Identification and characterization of a novel germ line p53 mutation in familial gastric cancer in the Japanese population. 17690113

2007

Entrez Id: 2065
Gene Symbol: ERBB3
ERBB3
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.420 AlteredExpression LHGDN High expression of HER3 is associated with a decreased survival in gastric cancer. 19047113

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.400 AlteredExpression LHGDN Increased expression of interleukin-1alpha and cyclooxygenase-2 in human gastric cancer: a possible role in tumor progression. 16101131

2005

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.400 AlteredExpression LHGDN Celecoxib could reverse the hypoxia-induced Angiopoietin-2 upregulation in gastric cancer. 16338068

2006

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.400 AlteredExpression LHGDN IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines. 18573283

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.400 AlteredExpression LHGDN Expression of COX-2 proteins in gastric mucosal lesions. 14716842

2004

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.400 AlteredExpression LHGDN Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer. 15386419

2005

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.400 AlteredExpression LHGDN Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation. 18430739

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.400 AlteredExpression LHGDN Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter pylori, and clinicopathologic characteristics of gastric carcinoma. 18462890

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.400 AlteredExpression LHGDN Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 18373164

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.400 AlteredExpression LHGDN [Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior]. 12452062

2002